We have a bunch of accounts that function as extra mailboxes — all conveniently housed in on OU. The following PowerShell command sets the password for all of the accounts in one go. Not terribly useful for “real world” use … but useful for testing (and probably something I’ll end up using again)

$OUpath = ‘ou=Mail Aliases,dc=example,dc=com’
$strNewPassword = “What3v3rYu0W@nt1tT0B3”

Get-ADUser -Filter * -SearchBase $OUpath | Set-ADAccountPassword -Reset -NewPassword (ConvertTo-SecureString -AsPlainText $strNewPassword -Force)